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KMID : 0981820100300040329
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Korean Journal of Laboratory Medicine
2010 Volume.30 No. 4 p.329 ~ p.333
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A Case of del(16)(q22) in a Patient with Acute Myeloid Leukemia with Complex Karyotype
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Kim Min-Ki
Lee Ji-Won
Lee Jin-Kyung
Hong Young-Joon
Hong Seok-Il
Kang Hye-Jin
Cho Eun-Hae
Jang Yoon-Hwan
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Abstract
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Inversion of chromosome 16 [inv(16)(p13.1q22)] and t(16;16)(p13.1;q22) are associated with acute myelomonocytic leukemia (AMML) with eosinophilia and a favorable prognosis. On the other hand, patients with del(16)(q22) usually present with MDS or chronic myelomonocytic leukemia (CMML), which can evolve to AMML without eosinophilia, and this chromosomal aberration is associated with older age, a complex karyotype, and a poor prognosis. We report a case of AML with del(16)(q22) which showed a complex karyotype, absence of eosinophilia in bone marrow study and a poor response to chemotherapy.
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KEYWORD
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AML, Deletion 16, Complex karyotype
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